From insertion to multicomponent coupling: temperature dependent reactions of arynes with aliphatic alcohols.
نویسندگان
چکیده
The temperature dependent selectivity switch in the reaction of arynes with aliphatic alcohols in THF has been reported. At -20 °C, arynes smoothly insert into the O-H bond of alcohols to form alkyl aryl ethers. Interestingly, at 60 °C, a highly selective multicomponent coupling occurs with the solvent THF acting as the nucleophilic trigger affording (4-(alkoxy)butoxy)arenes.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 8 شماره
صفحات -
تاریخ انتشار 2016